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Manchester United would welcome back midfielder Bruno Fernandes, who missed the win against Burnley through suspension.
Ralf Rangnick is optimistic Victor Lindelof will be available after a Covid absence.
While Midfielder Paul Pogba remains out with a thigh issue.
Wolves' game at Arsenal on Tuesday was postponed because of Covid but head coach Bruno Lage said on Friday there had been no further positive tests.
Hwang Hee-chan, Yerson Mosquera, Pedro Neto and Jonny remain long-term absentees.
Wolves are winless in 10 league games away to Manchester United since beating them at Old Trafford in February 1980 (D3, L7). They have scored a total of three goals during this run.
United could register a fourth successive top-flight win against Wolves for the first time since a sequence of five victories between 1964 and 1968.
Manchester United have won their opening league game in five of the past six calendar years, with the exception a 2-0 loss at Arsenal in 2020.
The Reds have won 65.5% of their Premier League matches in January, the best record of any team in the competition's history.
They are unbeaten in five league and cup games under Ralf Rangnick, taking 10 points from a possible 12 in the league.
United have lost just one of their past 17 league fixtures on a Monday, with that defeat coming against Tottenham in August 2018.
Wolves have not won their first game of the calendar year in any of their seven previous Premier League campaigns (D2, L5). Their most recent such victory as a top-flight side came in 1981 against Middlesbrough.
Their total of 13 top-flight goals is the club's lowest figure at the turn of the year since the 1981-82 season.
They have won just four of their 16 Premier League matches played on Mondays (D4, L8) - their lowest win ratio on a day of the week on which they have played more than once.
Adama Traore and Trincao have both attempted 21 shots without scoring in the Premier League this season, the joint-highest figure in the division prior to the latest round of matches.
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