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Liverpool will travel to Southampton to face the Saints in a rescheduled Premier League game that will take place on Tuesday at St. Mary's.
Jurgen Klopp's side beat Chelsea on penalties for the second time this season to clinch the FA Cup trophy just a few months after winning the Carabao Cup at Wembley.
Fabinho will miss the trip to Southampton due to injury, while Virgil van Dijk and Mohamed Salah are doubtful after being replaced in the final due to knocks.
Andrew Robertson was replaced by Kostas Tsimikas due to cramp and the Greek left-back, who netted the winning penalty on Saturday, could start in defence alongside Trent Alexander-Arnold, Joel Matip and Ibrahima Konate.
Liverpool need to grab all three points or avoid a defeat away at Southampton to remain in the title race, with Manchester City being four points above them in the Premier League table.
As for the Saints, Valentino Livramento is sidelined through a serious injury, while Fraser Forster and Stuart Armstrong are doubtful due to injuries.
Southampton have mathematically secured safety with two games to go and have nothing to play in their last home game of the 2021/22 campaign.
Southampton vs Liverpool predicted line-ups
Southampton's predicted line-up (4-4-2): Alex McCarthy; Kyle Walker-Peters, Jan Bednarek, Mohamed Salisu, Romain Perraud; Mohamed Elyounoussi, James Ward-Prowse, Oriol Romeu, Nathan Tella; Che Adams, Armando Broja.
Liverpool's predicted line-up (4-3-3): Alisson; Trent Alexander-Arnold, Joel Matip, Ibrahima Konate, Kostas Tsimikas; Naby Keita, Jordan Henderson, Thiago Alcantara; Diogo Jota, Sadio Mane, Luis Diaz.
Where to watch Southampton vs Liverpool?
For fans in the United Kingdom, the game is live on Sky Sports Premier League and Main Event. If you're in the USA, the game will be broadcast by UNIVERSO NOW, USA Network and UNIVERSO.
Livestream Southampton vs Liverpool Below:
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